Peptide Catagory
PT-141 Bremelanotide 10mg

PT-141 or Bremelanotide is the generic term for a research peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). PT-141 was developed from the tanning peptide Melanotan 2, which is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis that is known as alpha-Melanocyte stimulating hormone. MSH, activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido. Resultantly, PT-141 has been shown in studies to exhibit libido-enhancing effects by activating the melanocortin receptors MC1R and MC4R, but not skin tanning. Melanotan 1 and Melanotan 2 have been researched for their use in protecting against the harmful effects of ultraviolet radiation from sunlight due to their melanogenesis-stimulating properties.

PT-141 is a potential remedy for the treatment of sexual dysfunction; specifically, male erectile dysfunction. Studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation. PT-141 is a melanocortin based peptide that has shown effectiveness in clinical studies on both male and female rats. Male rats have shown erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive results with higher doses around 2-3 mgs. While the dosage requirements tend to be higher for female rats, the observable results in female rats tend to be stronger.

HGH Fragment 176-191 5mg

Growth Hormone peptide fragment 176-191, also known as HGH Frag 176-191, is a modified form of amino acids 176-191 of the GH polypeptide. Investigators at Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the Growth Hormone molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. It works by mimicking the way natural Growth Hormone regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified Growth Hormone. Like Growth Hormone, the hgH fragment 176-191 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis (the transformation of nonfat food materials into body fat) both in laboratory testing and in animals and humans.

In laboratory tests on fat cells from rodents, pigs, dogs, and humans, the hgH fragment released fat specifically from obese fat cells but not from lean ones, reduced new fat accumulation in all fat cells, enhanced the burning of fat. In rodents (rats and mice), hgH fragment reduced body fat in obese animals but, enhanced fat burning without changing food consumption or inducing growth (as it does not increase IGF levels) or any other unwanted Growth Hormone effect. Research dosages of 500mcg of the hgH fragment 176-191 daily for 30 days did show a reduction of body fat in the mid abdominal area in both obese, over-weight, and average built people.

MGF - Mechano Growth Factor 5mg

Mechano growth factor (MGF) is a novel splice variant of the insulin growth factor -1 (IGF-1), also known as IGF-1Ec in humans and IGF-1Eb in rodents. It is actually originally called MGF because the RNA form of it is expressed in muscle tissues in response to the overload or/and damage. The C-terminal peptide of the mechano growth factor (MGF) is a crucial region for the alternative splicing of the peptide. The alternative splicing in the MGF is brought about by the shift in the reading frame in which a specific C-terminal sequence (E-domain) is econded by exon 5 and the first part of the exon 6. Another interesting point in MGF is that, because of the E domain it contains, MGF can act on muscles independently from the rest of the molecule. Furthermore, MGF can elicit very different effects with mGF promoting satellite cells proliferation and IGF-1 inducing differentiation (Dluzniewska et al. 2005).

MGF was suggested to play a number of physiological roles because the failure in its expression may result to age-related loss of skeletal function. Included in its functions is its ability to become a potent neuroprotective as supported by the study that has shown functional copies of the MGF cDNA to be expressed in a plasmid vector which then protected facial neurons after nerve damage (Dluzniewska et al. 2005). One such failure is called sarcopenia.
When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene is released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue

Melanotan-II 10mg




























Melanotan II (PT-14) is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH).

Melanotan 2 (MT-2) is a man-made version of alpha melanocyte stimulating hormone (MSH), a melanocortin peptide hormone. It was first synthesized by researchers at the University of Arizona for melanogenesis, and to increase libido effects in men. The peptide mimics melanogenesis and UV-protective effects of Melanotan 1. However, recent research evidences suggest aphrodisiac effects of Melanotan 2. Due to protective effects against harmful UV rays, it is being studied as a potential prophylaxis against melanoma (skin cancer). The synthetic chemical is contraindicated for consumption, diagnosis or treatment in humans, and strictly for research purpose only. The molecular weight and formula is 1024.2 and C50H69N15O9, respectively.

Studies indicate that MSH has a considerable effect on appetite, lipid metabolism, and sexual libido via the melanocortin receptors. Studies have been done to determine its effectiveness as appetite suppressant, libido enhancing properties and appetite suppressant properties. Moreover, Melanotan 2 has shown efficacy in combating erectile dysfunction and other sexual dysfunction related conditions.Melanotan II has shown to be effective in increasing libido, and has aphrodisiac properties. The hormone is a cyclic heptapeptide analog of alpha MSH. Research indicates that Melanotan 2 activates the central melanocortin, which in turn triggers melanogenesis, and skin tanning occurs. Melanotan II reduces the serum levels of cholesterol and insulin, moreover further studies indicate that it lowers the levels of acetylcholine, a carboxylase expression and in other cases, it inhibited the reduction of palmitoltransferase I mRNA, and carnitine. This shows that the hormone increases cholesterol metabolism and fat catabolism.